Sativex is an emergent treatment option for spasticity in patients affected by multiple sclerosis (MS). This oromucosal spray, acting as a partial agonist at cannabinoid receptors, may modulate the balance between excitatory and inhibitory neurotransmitters, leading to muscle relaxation that is in turn responsible for spasticity improvement. Nevertheless, since the clinical assessment may not be sensitive enough to detect spasticity changes, other more objective tools should be tested to better define the real drug effect. The aim of our study was to investigate the role of Sativex in improving spasticity and related symptomatology in MS patients by means of an extensive neurophysiological assessment of sensory-motor circuits. To this end, 30 MS patients underwent a complete clinical and neurophysiological examination, including the following electrophysiological parameters: motor threshold, motor evoked potentials amplitude, intracortical excitability, sensory-motor integration, and Hmax/Mmax ratio. The same assessment was applied before and after one month of continuous treatment. Our data showed an increase of intracortical inhibition, a significant reduction of spinal excitability, and an improvement in spasticity and associated symptoms. Thus, we can speculate that Sativex could be effective in reducing spasticity by means of a double effect on intracortical and spinal excitability. Cannabidiol is a popular natural remedy used for many common ailments. Better known as CBD, it is one of the 104 chemical compounds known as cannabinoids found in the cannabis or marijuana plant, Cannabis sativa. Tetrahydrocannabinol (THC) is the main psychoactive cannabinoid found in cannabis, and causes the sensation of getting “high” that’s often associated with marijuana. However, unlike THC, CBD is not psychoactive. This quality makes CBD an appealing option for those who are looking for relief from pain and other symptoms without the mind-altering effects of marijuana or certain pharmaceutical drugs. CBD oil is made by extracting CBD from the cannabis plant, then diluting it with a carrier oil like coconut or hemp seed oil. It’s gaining momentum in the health and wellness world, with some scientific studies confirming it may help treat a variety of ailments like chronic pain and anxiety. Here are seven health benefits of CBD oil that are backed by scientific evidence. Florida marijuana doctors–Florida Marijuana Doctors and other physicians show improvement with the use of CBD as far back as 2900 B.C. More recently, scientists have discovered that certain components of marijuana, including CBD, are responsible for its pain-relieving effects. The human body contains a specialized system called the endocannabinoid system (ECS), which is involved in regulating a variety of functions including sleep, appetite, pain and immune system response. The body produces endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors in your nervous system. Studies have shown that CBD may help reduce chronic pain by impacting endocannabinoid receptor activity, reducing inflammation and interacting with neurotransmitters. For example, one study in rats found that CBD injections reduced pain response to surgical incision, while another rat study found that oral CBD treatment significantly reduced sciatic nerve pain and inflammation. Several human studies have found that a combination of CBD and THC is effective in treating pain related to multiple sclerosis and arthritis. An oral spray called Sativex, which is a combination of THC and CBD, is approved in several countries to treat pain related to multiple sclerosis. In a study of 47 people with multiple sclerosis, those treated with Sativex for one month experienced a significant improvement in pain, walking and muscle spasms, compared to the placebo group. Another study found that Sativex significantly improved pain during movement, pain at rest and sleep quality in 58 people with rheumatoid arthritis. Anxiety and depression are common mental health disorders that can have devastating impacts on health and well-being. According to the World Health Organization, depression is the single largest contributor to disability worldwide, while anxiety disorders are ranked sixth. Anxiety and depression are usually treated with pharmaceutical drugs, which can cause a number of side effects including drowsiness, agitation, insomnia, sexual dysfunction and headache. What’s more, medications like benzodiazepines can be addictive and may lead to substance abuse. CBD oil has shown promise as a treatment for both depression and anxiety, leading many who live with these disorders to become interested in this natural approach. In one study, 24 people with social anxiety disorder received either 600 mg of CBD or a placebo before a public speaking test. The group that received the CBD had significantly less anxiety, cognitive impairment and discomfort in their speech performance, compared to the placebo group. CBD oil has even been used to safely treat insomnia and anxiety in children with post-traumatic stress disorder. CBD has also shown antidepressant-like effects in several animal studies. These qualities are linked to CBD’s ability to act on the brain’s receptors for serotonin, a neurotransmitter that regulates mood and social behavior.